Clem Jones Centre for Ageing Dementia Research (CJCADR)

Queensland Brain Institute, The University of Queensland

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Prof Jürgen Götz

The Clem Jones Centre for Ageing Dementia Research (CJCADR), based at the Queensland Brain Institute at The University of Queensland, is a multidisciplinary research centre established to address the growing health and economic burden of dementia.

Founded through philanthropic, state and federal support, the Centre builds national research capacity and advances Australia's contribution to dementia research.

The Centre undertakes integrated research spanning fundamental discovery through to translational application. Its research is driven by the principle that a detailed understanding of disease mechanisms is essential to enable the development of effective interventions. This includes the development of novel therapeutic approaches, improved diagnostic tools and biomarkers, and new research technologies to better understand pathological processes.

Website
http://www.qbi.uq.edu.au/clem-jones-centre-ageing-dementia-research-cjcadr
Organisation type
  • University Research Centre
Number of research staff
20-100 research staff
Address
Queensland Brain Institute, The University of Queensland, Building 79, St Lucia, Brisbane QLD 4072

Strengths and capabilities

  • Therapeutic and diagnostic development
  • Neural regeneration and cognition
  • Molecular and cellular neuroscience
  • Cognitive and clinical neuroscience
  • Systems biology and cell neurochemistry
  • Epigenetics and mitochondrial biology
  • Gene editing technologies
  • Transgenic and disease models
  • Proteomics and molecular interactions
  • Transcriptomics and lipidomics
  • Super-resolution microscopy
  • Low-intensity ultrasound related technologies
  • DNA and protein engineering
  • Antibody and nanobody technologies

Facilities and major equipment

  • PC2-certified laboratory facilities
  • Tissue culture laboratories
  • Animal behaviour facility
  • Advanced microscopy facility
  • Two-photon microscopy facility
  • Histology and imaging facility
  • Super-resolution microscopy platforms
  • Molecular and cellular analysis platforms
  • DNA sequencing platforms
  • Electrophysiology recording systems
  • Flow cytometry systems
  • Ultrasound equipment

Lead researchers

  • Professor Jürgen Götz, CJCADR Director, internationally recognised Alzheimer's disease researcher and Fellow of the Australian Academy of Science.
  • The Centre comprises 10 research group leaders, each leading multidisciplinary teams with specialised expertise, collectively supporting integrated research across discovery, translation and clinical application.

Achievements of the centre

  • Establishment of an integrated discovery-to-translation pipeline progressing multiple therapeutic, diagnostic and device-based innovations towards clinical application and commercialisation pathways.
  • Discovery that non-invasive ultrasound therapy can reduce amyloid plaques and restore memory in preclinical Alzheimer's disease models, supporting development of novel therapeutic approaches.
  • Identification that specific exercise regimes stimulate hippocampal neurogenesis in ageing models, improving learning and supporting translation to interventions targeting cognitive decline in older populations.
  • Discovery that free fatty acids play a critical role in memory acquisition, highlighting new metabolic pathways and potential therapeutic targets for neurodegenerative diseases including Alzheimer's disease.

Key science sectors

More information about the sectors this centre is involved in:

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