Base Facility

The University of Queensland

Modern laboratory interior with clean white benches and equipment, including red incubators and analytical instruments, arranged along both sides of a narrow workspace. A yellow door and wall panel are visible at the back, alongside a wall-mounted sink and safety signage. Overhead fluorescent lighting and reflective glass partitions create a bright, sterile research environment with stools and storage units positioned under benches.

BASE facility provides end-to-end mRNA research services - from initial sequence design and mRNA manufacture through to LNP formulation - to support the development of mRNA medicines.

Our team has expertise in building mRNA medicines for a wide range of clinical applications including vaccines, cancer, immunotherapies, protein replacement, antibodies, and gene and cell therapies.

We have built over 1000 different mRNAs for use by academic and industry partners.Whether you are starting in discovery or working towards the clinic, BASE can help with the services and experience to develop new mRNA medicine.

Website

https://basefacility.org.au

Organisation type

University Research Centre
National Collaborative Research Infrastructure Scheme facility
Not-for-profit

Number of research staff

Up to 20 research staff

Address

AIBN Building (75), The University of Queensland, St Lucia QLD 4072

Strengths and capabilities

mRNA sequence engineering, design and optimisation
mRNA manufacturing and quality control
mRNA Lipid Nanoparticle Formulation and quality control

Facilities and major equipment

Research Facility located at the Australian Institute of Bioengineering and Nanotechnology (AIBN) at the University of Queensland
Production Facility based at Translational Research Insitute (TRI) of Australia
GLP compliant laboratory

Achievements of the centre

Manufactured over 1000 different mRNA medicines across wide range of clinical applications including vaccines, cancer, immunotherapies, protein replacement, antibodies, and gene and cell therapies
Designed and developed in-house mRNArchitect software for mRNA sequence design
Published mRNA manufacturing workflow in Nature Protocols
Developed NGS workflow for mRNA quality control

Key science sectors

More information about the sectors this centre is involved in:

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