Australian Organoid Facility (AOF)

The Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland

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Researcher at a computer screen at the Australian Organoid Facility

The Australian Organoid Facility (AOF), based at The University of Queensland's AIBN, is a NCRIS-supported research infrastructure facility providing access to human organoid models, automation-enabled culture workflows, high-content imaging, assay development and data analysis.

AOF supports academic, clinical and industry partners to generate, quality-control and apply 3D cell culture models for discovery biology, disease modelling, pre-clinical testing and translational research.

The facility combines specialist stem cell and organoid expertise with robotic automation, controlled laboratory practices and project-based scientific support to improve reproducibility, scalability and access to advanced human-relevant model systems.

Website
https://aibn.uq.edu.au/aof
Organisation type
  • National Collaborative Research Infrastructure Scheme facility
Number of research staff
Up to 20 research staff
Address
Level 4 west, Building 75,
The Australian Institute for Bioengineering and Nanotechnology (AIBN),
Corner College and Cooper Roads,
St Lucia campus,
The University of Queensland,
Brisbane QLD 4072
Australia

Strengths and capabilities

  • automated organoid generation
  • human 3D cell culture models
  • iPSC-derived brain organoids
  • intestinal organoid culture
  • liver and epithelial organoid models
  • cancer spheroid assays
  • organoid assay development
  • robotic liquid handling workflows
  • high-content confocal imaging
  • image-based phenotypic analysis
  • live/dead and viability assays
  • organoid drug testing workflows
  • scalable culture optimisation
  • quality-controlled project workflows
  • project reporting and data summaries

Facilities and major equipment

  • 2 Cell Explorer Cell Culutre automation systems with a phenix and operetta HC imager and Celigo Cytometer
  • ChemagicTM 360 for automated nucleic extraction
  • Tissue culture and molecular biology suites
  • Fluoresence microscopes
  • Dedicated high PC2 facility
  • Freezers and liquid nitrogen storage

Achievements of the centre

  • Developed bespoke organoid models for clients to address specific biological questions in translational and pre-clinical research.
  • Established a not-for-profit automation facility providing quality-assured organoids for translational and contract research.
  • Implemented the AOF Explorer G3 Workstation to automate organoid production, screening and analysis.
  • Partnered with Revvity to establish advanced automation workflows supporting reproducibility and quality control.
  • Featured by Phenomics Australia as part of Brisbane's national in vitro disease-modelling capability.

Key science sectors

More information about the sectors this centre is involved in:

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